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Side Effects

Side Effects

2017·Jen Igartua, Jade Shames, Kat Thek

2 - 8 players
10 - 30 min
Light weight: Learn it in minutes

From BoardGameGeek

Drug use, personal demons, wild episodes, and more. Side Effects is a "take that" card game where players race to treat all the diseases in their psyche with medication and therapy. Players start with four disease cards dealt face up in front of them (their "psyche") and then four cards in a concealed hand. Players take turns picking up cards from the deck and trying to find the right drugs to treat their diseases. A drug card will treat a disease but also leave the player open to receiving new diseases (of that drug's list of side effects) from other players. Each disease card has a unique punishment written on it and episode cards will trigger these punishments. Play an episode card on another player to hinder them or help yourself. The game is over when one player treats all of the diseases in their psyche.

Side Effects

Watch first

Learn to play

Side Effects Card Game - Unboxing, How-To, & Playthrough24:15

Side Effects Card Game - Unboxing, How-To, & Playthrough

Skytiger Gaming

Skytiger Gaming

Review

Episode #330 - Side Effects & Booster Shot Expansion (2017 & 2023)21:25

Episode #330 - Side Effects & Booster Shot Expansion (2017 & 2023)

BOARD GAME MAN

BOARD GAME MAN

Which Side Effects video should I watch?

Side Effects has 2 videos from 2 creators: 1 review and 1 how-to-play guide. They date from 2024 to March 2026.

To learn the rules, start with "Side Effects Card Game - Unboxing, How-To, & Playthrough" by Skytiger Gaming, which runs 24 min.

For an opinion before you buy, start with "Episode #330 - Side Effects & Booster Shot Expansion (2017 & 2023)" by BOARD GAME MAN.

If you like it, try Hex Effects, MUD, Dead Letters and All True Believers, also by Jade Shames.

All videos

Episode #330 - Side Effects & Booster Shot Expansion (2017 & 2023)Review21:25

Episode #330 - Side Effects & Booster Shot Expansion (2017 & 2023)

BOARD GAME MAN

BOARD GAME MAN

Side Effects Card Game - Unboxing, How-To, & PlaythroughHow to play24:15

Side Effects Card Game - Unboxing, How-To, & Playthrough

Skytiger Gaming

Skytiger Gaming

Creators who cover this

All channels
BOARD GAME MAN
BOARD GAME MAN
1 video of this game
Skytiger Gaming
Skytiger Gaming
1 video of this game

Games like this

All games

Hex Effects

2025·Ben Bronstein, Jade Shames, Kat Thek

Videos
5
Creators
4
Mainly reviews

2 - 8 players·10 - 30 min·Light weight

MUD

2020·Ben Bronstein, Jen Igartua, Jade Shames, Kat Thek

Videos
3
Creators
3
Mostly reviews

2 - 6 players·20 - 40 min·Medium weight

Dead Letters

2026·Jade Shames

Videos
3
Creators
3
Mostly how-to-play

1 - 7 players·5 - 30 min

AT

All True Believers

2027·Ben Bronstein, Jade Shames

Videos
3
Creators
3
Some how-to-play

5 - 10 players·45 - 90 min

About Side Effects

From BoardGameGeek:

Drug use, personal demons, wild episodes, and more. Side Effects is a "take that" card game where players race to treat all the diseases in their psyche with medication and therapy. Players start with four disease cards dealt face up in front of them (their "psyche") and then four cards in a concealed hand. Players take turns picking up cards from the deck and trying to find the right drugs to treat their diseases. A drug card will treat a disease but also leave the player open to receiving new diseases (of that drug's list of side effects) from other players. Each disease card has a unique punishment written on it and episode cards will trigger these punishments. Play an episode card on another player to hinder them or help yourself. The game is over when one player treats all of the diseases in their psyche.

Designers

Jen Igartua, Jade Shames, Kat Thek

Artist

Ben Bronstein

Publisher

Pillbox Games

Categories

Card GameMature / AdultParty GameRacing

Mechanics

Take That
View on BoardGameGeek ›
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