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Mar 3, 2026·How to play·24:15·10·Watch on YouTube

Side Effects Card Game - Unboxing, How-To, & Playthrough

Skytiger Gaming

Skytiger Gaming

Watch “Side Effects Card Game - Unboxing, How-To, & Playthrough,” a how-to-play guide for Side Effects from Skytiger Gaming on BoardGameVideo.

Description provided by Skytiger Gaming on YouTube:

Side Effects Card Game - Unboxing, How-To, & Playthrough Dive into the quirky card game of Side Effects! In this video, we break down how the game works, explore its clever card interactions, and play through a full match to show the chaos, combos, and strategy in action. Perfect for anyone curious about this fast, funny, and unpredictable card game. 🔽 CHAPTERS 🔽 00:00 Intro 00:12 Side Effects - Unboxing 02:10 Box Lid Off 04:00 The Cards 05:50 Side Effects - How to Play 10:00 Game Setup 12:25 Side Effects - Game Start 13:23 First Therapy Card Play 15:03 First You're Having an Episode Play 18:33 First Med Played & Card Limit 19:16 First Disorder Played 22:18 Last Round & Wrap Up 👉 Subscribe for more playthroughs, unboxings, and board game content from Skytiger Gaming. 💥 Be sure to turn on Klingon Subtitles for any rules corrections and mistakes overlooked during game play. 💥 #sideeffects #sideeffectscardgame #pillboxgames #cardgames #BoardGameUnboxing #BoardGameCommunity #TabletopGames #TabletopUnboxing #FamilyBoardGames #FamilyGameNight #SkytigerGaming

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Side Effects

Side Effects

2017·Jen Igartua, Jade Shames, Kat Thek

2 - 8 players
10 - 30 min
Light weight: Learn it in minutes

About Side Effects, from BoardGameGeek:

Drug use, personal demons, wild episodes, and more. Side Effects is a "take that" card game where players race to treat all the diseases in their psyche with medication and therapy. Players start with four disease cards dealt face up in front of them (their "psyche") and then four cards in a concealed hand. Players take turns picking up cards from the deck and trying to find the right drugs to treat their diseases. A drug card will treat a disease but also leave the player open to receiving new diseases (of that drug's list of side effects) from other players. Each disease card has a unique punishment written on it and episode cards will trigger these punishments. Play an episode card on another player to hinder them or help yourself. The game is over when one player treats all of the diseases in their psyche.

Designers

Jen Igartua, Jade Shames, Kat Thek

Artist

Ben Bronstein

Publisher

Pillbox Games

Categories

Card GameMature / Adult

Mechanics

Take That
View on BoardGameGeek ›
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Side Effects Card Game - Unboxing, How-To, & Playthrough