Pandora's Box Card Game

From BoardGameGeek:

Pandora's Box is the epic strategy game fit for the Gods. This fast-paced, high-energy card game is easy to learn and hilarious to play. As mortals you are trying to reveal your 4 columns (8 cards) to appease the gods while avoiding curses and lock/keys. The game is simple, match the god character cards, top and bottom, in your columns to cancel out the points. If you match multiple adjacent columns with the same god you score a Midas Touch which gives you negative points. Finally, if you are the first one to reveal all cards in your columns you get negative bonus points. The player that gets the fewest points wins. While that may seem simple, the gods are full of passion and your opponents are full of fury so be ready for curse cards that inflict pandemonium and lock/key cards that stop you from changing the cards in your columns. The core deck is designed for 2-5 players and the party expansion is designed for 6-10 players. Typical game-play time is 15 minutes per round. Ideal for friends and families that love strategy, laughter, spite, and glory. Appropriate for ages 8 and up. -description from the designer