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From BoardGameGeek:

"How well do you know your friends?" Pick someone you think you know well. Randomly pick a card from the deck and read it aloud (doesn't matter who). From the choices on the card, write down your choice under the "Me" column and write down what you think your teammate wrote down under the "Not Me" column. Repeat for all 8 question cards in the round. Once you're done with the round, compare answers question-by-question, team-by-team. If you and your teammate pick correctly for each other (you get theirs right and they get yours right), you get 1 team point. Anything else is 0 points. The team with the total number of team points after all 3 rounds wins the game. There are two main additional ways to play: Party Mode and 1-on-1. For Party Mode, one person reads each question out loud and people shout out what they would choose. Then everyone argues about why they're right and everyone else is wrong. For 1-on-1, you and that someone you think you know well are the only team playing. Which one of you knows the other person better? -description from the designer