Hero Brigade

From BoardGameGeek:

Hero Brigade is a fast-paced heroic card game for 1-2 players that features elements of deck-building and positional card-battling. Take on the role of the Heroes or the Villains and prepare to throw down! Each character card can be played in three different ways (deployed to your Party's Front Row, deployed to your Support Row, or used for a one-time game effect). Hero Brigade also offers unique twists on conventional deck-building mechanisms. Drawing extra cards and eliminating your starting cards can hurt you in the long term as you permanently lose cards from your deck each time you reshuffle and each time one of your characters is defeated. Running out of cards loses you the game!