Go F**k Yourself

From BoardGameGeek:

Be the player with the most completed sets of embarrassing situation cards by the end of the game. This is an adult version of the classic "Go Fish" game with inappropriate cards like "mismatched boobies" and "an underaged girlfriend". The point being that when asking if another player has a card, you ask, "Do you have " (ex: Do you have "bad breath"). If the player does, he hands all cards matching that to the asker. If not, he replies "Go Fuck Yourself". Once a player has a full set of that card type (4 cards), he puts those cards aside and gets a point for completing the set.